张 莹，罗彦玉，王 磊，秦礼康^*，贾玉龙^*

（贵州大学酿酒与食品工程学院，贵州贵阳 550025）

摘要：本文以高脂饮食小鼠模型为主要研究对象，初步评价油茶籽油微胶囊对高脂饮食小鼠模型的降脂作用。通过分析高脂饮食小鼠血清中血脂影响的关键因子TG、TC、LDL-C、HDL-C的相对含量及肝脏氧化代谢调控关键酶活力水平，综合评价油茶籽油微胶囊对高脂饮食小鼠的降脂作用。结果表明，油茶籽油微胶囊实验组和普通饲料对照组的脏器指数差异不显著（P＞0.05），但显著低于高脂模型组的脏器指数（P＜0.05）；油茶籽油微胶囊实验组能够抑制小鼠高脂饮食引起的血清中TG、TC和LDL-C含量的升高；油茶籽油微胶囊提高CAT活力的能力高于油茶籽油，表明油茶籽油微胶囊能有效提高小鼠肝脏中抗氧化酶的活力。剖析小鼠肠道菌群物种分布情况变化，喂养油茶籽油微胶囊能提高高脂饮食小鼠肠道菌群中瘤胃球菌科（Ruminococcaceae）、普雷沃氏菌科（Prevotellaceae）、理研菌科（Rikenellaceae）、普雷沃氏菌属（Alloprevotella）和另枝菌属（Alistipes）的相对丰度。

关键词：油茶籽油，微胶囊，小鼠高脂模型，降血脂

中图分类号：TS225.16    文献标识码：A    文章编号：1674-506X（2022）03-0056-0008

Study on the Hypolipidemic Function of Camellia oleifera Seed Oil Microcapsules on High-fat Diet Mouse Model

ZHANG Ying, LUO Yanyu, WANG Lei, QIN Likang^*, JIA Yulong^*

（School of Liquor and Food Engineering, Guizhou University, Guiyang Guizhou 550025, China）

Abstract：In this paper, the high-fat diet mouse model was used as the main research object to preliminarily evaluate the anti-hyperlipidemia of Camellia oleifera seed oil microcapsules on the high-fat diet mouse model. By analyzing the content of TG, TC, LDL-C, HDL-C, the key factors affecting blood lipids in the serum of high-fat diet mice, and the stress level of enzymes related to the regulation of liver oxidative metabolism. Comprehensive evaluation of the regulatory effect of Camellia oleifera seed oil microcapsules on high-fat diet mice. The results were shown that there was no significant difference in the organ index between the common feed control group and the Camellia oleifera seed oil microcapsules group (P＞0.05), but it was significantly lower than that of the high-fat model group (P＜0.05). Camellia oleifera seed oil microcapsules group could inhibit the increase of serum TG, TC and LDL-C contents in the high-fat diet model mice. The ability of the Camellia oleifera seed oil microcapsules to improve the CAT activity was higher than that of the Camellia oleifera seed oil. That were indicating that the Camellia oleifera seed oil microcapsules could effectively improve the activity of antioxidant enzymes in the liver of mice. Analyzing the changes in the distribution of intestinal flora species in mice, Camellia oleifera seed oil microcapsules could increase the relative abundance of Ruminococcaceae, Prevotellaceae, Rikenellaceae, Alloprevotella and Alistipes in the intestinal flora of mice fed a high-fat diet.

Keywords：Camellia oleifera seed oil; Camellia oleifera seed oil microcapsules; mice high-fat model; hypolipidemic

doi：10.3969/j.issn.1674-506X.2022.03-008

收稿日期：2022-04-05

基金项目：贵州大学人才引进科研项目-人基合字（2019）第16号（自然科学）资助；贵州省林业局特色林业科研项目（特林研2020-03）；贵州省科技厅科技支撑定向重点项目（黔支撑重点［2022］009号）；贵州省特色林业科研项目（特林研2020-19）

作者简介：张莹（1997-），女，硕士研究生。研究方向：食品科学。

*通信作者：秦礼康（1965-），男，博士，教授。研究方向：食品科学；贾玉龙（1988-），男，博士，讲师。研究方向：食品科学。

引用格式：张莹,罗彦玉,王磊,等.油茶籽油微胶囊对高脂饮食小鼠模型的降脂作用[J].食品与发酵科技,2022,58(3):56-63.